The paper discusses the effectiveness of a knowledge management system which is the result of the efficient transfer of knowledge in the market environment, in this case between scientific institutions and other institutions and enterprises in the region. Careful analysis of the literature, past experience and results of studies carried out under the “Know-how — effective communication in the regional transfer of knowledge”, provided for the formulation and above all an understanding of the expectations of “recipients” of knowledge as to the object implementation and management process and knowledge transfer.
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